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货号： bs-7126R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-7126R
- 英文名称
- FKBP6
- 中文名称
- 旋转异构酶FKBP6抗体
- 别 名
- 36 kDa FK506 binding protein; 36 kDa FK506-binding protein; 36 kDa FKBP; EC 5.2.1.8; FK506 binding protein 6; FK506-binding protein 6; FKBP 36; FKBP-36; FKBP-6; FKBP36; fkbp6; FKBP6_HUMAN; Immunophilin FKBP36; Peptidyl prolyl cis trans isomerase; Peptidyl-prolyl cis-trans isomerase FKBP6; PPIase; PPIase FKBP6; Rotamase.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 心血管 发育生物学 生长因子和激素 t-淋巴细胞
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 37kDa
- 细胞定位
- 细胞核 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human IL-17F:31-130/327
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
FKBP6 is a 327 amino acid protein that, like other PPIases, accelerate the folding of proteins. As a component in synaptonemal complexes, FKBP6 is involved in homologous chromosomes pairing and male infertility in mice. There has been some suggestion that FKBP6 may play a role in modifying the susceptibility to idiopathic spermatogenic impairment in humans. Ubiquitously expressed in all tissues, FKBP6 is present at highest levels in testis, liver, kidney, skeletal muscle and heart. The gene encoding FKBP6 maps within a region of human chromosome 7 that has been implicated in Williams-Beuren syndrome, a rare developmental disorder involving abnormalities of the cardiovascular and musculoskeletal systems. Hemizygous deletion of FKBP6 may contribute to hypercalcemia and growth delay in Williams-Beuren syndrome.
Function:
PPIases accelerate the folding of proteins.
Tissue Specificity:
Detected in all tissues examined, with higher expression in testis, heart, skeletal muscle, liver, and kidney.
DISEASE:
Note=FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.
Similarity:
Contains 1 PPIase FKBP-type domain.
Contains 3 TPR repeats.
SWISS:
O75344
Gene ID:
8468
Database links:Entrez Gene: 8468 Human
Entrez Gene: 94244 Mouse
Entrez Gene: 288597 Rat
Omim: 604839 Human
SwissProt: O75344 Human
SwissProt: Q91XW8 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.