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货号： bs-13178R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-13178R
- 英文名称
- FKBP25
- 中文名称
- 肽基脯氨酸异构酶酶FKBP25抗体
- 别 名
- FKBP 25; FKBP 3; FKBP25; FKBP3; PPIase; Rotamase; FKBP3_HUMAN.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 25kDa
- 细胞定位
- 细胞核
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human FKBP25:31-130/224
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
FKBP25 is a member of the immunophilin protein family. The immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases that bind to and mediate the effects of immunosuppressive drugs, such as cyclosporin, FK506 and rapamycin. They inhibit T-cell proliferation by interrupting two specific cytoplasmic signal transmission pathways. FKBP25 is localized in the nucleus and is expressed in the brain, testis, ovary, and spleen. It may influence immunoregulation and cerebellum development, as well as protein folding and trafficking in neurons. FKBP25 associates with transcriptional repressor protein YY1 and histone deaceltylases, HDAC1 and HDAC2. FKBP25 may contain several casein kinase II phosphorylation sites, which are believed to be important for cell growth regulation.
Function:
FK506 binding proteins (FKBPs) are peptidyl proline isomerase enzymes (catalyzing the interconversion of cis-> trans proline in proteins). Cytosolic FKBPs are inhibited by the immunosuppressive drugs FK506 and rapamycin, and regulate calcineurin signalling in T cells. A unique member of the FKBP family is FKBP25 (also known as FKBP3). It is localized to the nucleus, and has been shown to interact with the transcription factor YY1 and HDAC enzymes. These observations suggest that FKBP25 may play a direct role in transcriptional regulation and chromatin modifications. FKBP25 has also been shown to be down-regulated following p53 induction.
Subcellular Location:
Nuclear
Similarity:
Belongs to the FKBP-type PPIase family.
Contains 1 PPIase FKBP-type domain.
SWISS:
Q00688
Gene ID:
2287
Database links:Entrez Gene: 515069 Cow
Entrez Gene: 2287 Human
Entrez Gene: 30795 Mouse
Entrez Gene: 100009004 Rabbit
Entrez Gene: 299104 Rat
Omim: 186947 Human
SwissProt: P26884 Cow
SwissProt: Q00688 Human
SwissProt: Q62446 Mouse
SwissProt: O46638 Rabbit
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.