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货号： bs-4782R-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-4782R-Cy3
- 英文名称
- Anti-HSPB2/Cy3
- 中文名称
- Cy3标记的热休克蛋白B2抗体
- 别 名
- DMPK-binding protein; Heat shock 27kD protein 2; Heat shock 27kDa protein 2; Heat shock protein beta-2; Heat-shock protein beta-2; Hs.78846; HSP27; HspB2; HSPB2_HUMAN; LOH11CR1K; MGC133245; MKBP.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 20kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from hu HSPB2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The heat shock proteins (HSPs) comprise a group of highly conserved, abundantly expressed proteins with diverse functions, including the assembly and sequestering of multi-protein complexes, transportation of nascent polypeptide chains across cellular membranes and regulation of protein folding. HSPB2 (heat shock 27 kDa protein 2), also known as HSP 27 or MKBP, is a 182 amino acid protein that belongs to the heat shock protein family and is expressed preferentially in heart and skeletal muscle. Localized to mitochondria, HSPB2 functions as an ATP-dependent chaperone protein that plays a role in the refolding of denatured proteins and may also interact with the Actin cytoskeleton and prevent apoptotic cell death. HSPB2 is abundantly expressed in several cancer cell lines, suggesting that HSPB2 may be an important factor in tumor transformation and metastasis.
Function:
May regulate the kinase DMPK.
Subunit:
Interacts with DMPK; may enhance its kinase activity.
Subcellular Location:
Cytoplasm. Nucleus. Localizes to nuclear foci.
Tissue Specificity:
Expressed preferentially in skeletal muscle and heart.
Similarity:
Belongs to the small heat shock protein (HSP20) family.
Database links:Entrez Gene: 508671Cow
Entrez Gene: 611362Dog
Entrez Gene: 100736126 Guinea pig
Entrez Gene: 101828097Hamster
Entrez Gene: 3316Human
Entrez Gene: 69253Mouse
Entrez Gene: 100520143Pig
Entrez Gene: 161476Rat
Omim: 602179Human
SwissProt: Q16082Human
SwissProt: Q99PR8Mouse
SwissProt: O35878Rat
Unigene: 709660Human
Unigene: 1980Mouse
Unigene: 22486Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.