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货号： bs-9378R-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9378R-Cy3
- 英文名称
- Anti-RNF61/MKRN1/Cy3
- 中文名称
- Cy3标记的环指蛋白61抗体
- 别 名
- RING finger protein 61; E3 ubiquitin-protein ligase makorin-1; Makorin; Makorin ring finger protein 1; MKRN 1; MKRN-1; mkrn1; MKRN1_HUMAN; Ring finger protein 1; RNF61.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 细胞周期蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 53kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MKRN1/RNF61
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.
Function:
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription.
Subunit:
Interacts with p53/TP53 and CDKN1A. Interacts with TERT, modulating telomere length homeostasis.
Tissue Specificity:
Ubiquitous.
Post-translational modifications:
Auto-ubiquitinated; which leads to proteasomal degradation.
Similarity:
Contains 4 C3H1-type zinc fingers.
Contains 1 RING-type zinc finger.
Database links:Entrez Gene: 23608 Human
Entrez Gene: 54484 Mouse
Entrez Gene: 296988 Rat
Omim: 607754 Human
SwissProt: Q9UHC7 Human
SwissProt: Q9QXP6 Mouse
Unigene: 728819 Human
Unigene: 270484 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.