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货号： bs-9467R-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-9467R-Cy3
- 英文名称
- Anti-Dishevelled 3/Cy3
- 中文名称
- Cy3标记的DVL3蛋白抗体
- 别 名
- Segment polarity protein dishevelled homolog DVL 3; Dishevelled 3 (homologous to Drosophila dsh); Dishevelled 3; Dishevelled 3, dsh homolog (Drosophila); Dishevelled, dsh homolog 3 (Drosophila); Dishevelled-3; DSH homolog 3; DVL-3; dvl3; DVL 3; DVL3_HUMAN; Segment polarity protein dishevelled homolog DVL-3.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 神经生物学 信号转导 细胞凋亡
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 78kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Dishevelled 3/DVL3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Mammalian homologs of the Drosophila dishevelled (Dsh) gene have been identified, including Dvl-1, Dvl-2 and Dvl-3. The mammalian dishevelled proteins contain three homologous domains, two of which are unrelated to any other known protein. The third region is homologous to the discs-large homology domain of Drosophila discs-large-1, a tumor suppressor protein. Like their Drosophila counterpart, the dishevelled proteins are thought to be in-volved in embryogenesis. Overexpression of Dvl-1 has been shown to inhibit the phosphorylation of tau by GSK-3b. This finding may prove to be important in Alzheimer’s studies, which have shown that tau is hyperphosphorylated. In Drosophila, Dsh is a component of the frizzled signaling pathway. Both mammalian dishevelled and frizzled proteins are components of the Wnt signalling pathway.
Function:
May play a role in the signal transduction pathway mediated by multiple Wnt genes.
Subunit:
Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2 (By similarity). Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction. Interacts with CYLD, CEP164 and DAB2.
Subcellular Location:
Cytoplasm.
Post-translational modifications:
Ubiquitinated. Deubiquitinated by CYLD, which acts on Lys-63-linked ubiquitin chains.
Phosphorylated by CSNK1D.
Similarity:
Belongs to the DSH family.
Contains 1 DEP domain.
Contains 1 DIX domain.
Contains 1 PDZ (DHR) domain.
Database links:Entrez Gene: 1857 Human
Entrez Gene: 13544 Mouse
Entrez Gene: 303811 Rat
Omim: 601368 Human
SwissProt: Q92997 Human
SwissProt: Q61062 Mouse
Unigene: 388116 Human
Unigene: 247259 Mouse
Unigene: 272443 Mouse
Unigene: 219497 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.