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货号： bs-13043R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-13043R
- 英文名称
- DYX1C1
- 中文名称
- DYX1C1蛋白抗体
- 别 名
- Dyslexia susceptibility 1 candidate 1; Dyslexia susceptibility 1 candidate gene 1 protein; DYX1; DYX1C1; DYXC1; DYXC1_HUMAN; EKN1; FLJ37882; MGC70618; RD.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul T), introduce a premature stop codon and truncate the protein by 4 amino acids. DYX1C1 encodes a nuclear tetratricopeptide repeat domain protein that is dynamically regulated in brain. In human brain, DYX1C1 protein localizes to a fraction of cortical neurons and white matter glial cells. It is also expressed in lung, kidney and testis.
Function:
Involved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity.
Subunit:
Interacts with ESR1 and ESR2. Interacts with STUB1.
Subcellular Location:
Nucleus. Cytoplasm.
Tissue Specificity:
Expressed in several tissues, including brain, lung, kidney and testis. In brain localizes to a fraction of cortical neurons and white matter glial cells.
DISEASE:
Defects in DYX1C1 may be a cause of susceptibility to dyslexia type 1 (DYX1) [MIM:127700]. A relatively common, complex cognitive disorder characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities. It is a multifactorial trait, with evidence for familial clustering and heritability. Note=A chromosomal aberration involving DYX1C1 has been found in a family affected by dyslexia. Translocation t(2;15)(q11;q21).
Similarity:
Contains 1 CS domain.
Contains 3 TPR repeats.
SWISS:
Q8WXU2
Gene ID:
161582
Database links:Entrez Gene: 453458 Chimpanzee
Entrez Gene: 161582 Human
Omim: 608706 Human
SwissProt: Q863A7 Chimpanzee
SwissProt: Q863A5 Gorilla
SwissProt: Q8WXU2 Human
SwissProt: Q863A4 Orangutan
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.