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货号： bs-12996R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-12996R
- 英文名称
- Dermcidin
- 中文名称
- 抗菌蛋白DCD抗体
- 别 名
- AIDD; DCD 1; dcd; DCD-1; DCD_HUMAN; DSEP; HCAP; PIF; Preproteolysin; Dermcidin.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 细菌及病毒 新陈代谢
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 11kDa
- 细胞定位
- 分泌型蛋白
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Dermcidin/DCD:63-109/110
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
Antimicrobial peptides participate in the innate response, which may provide a barrier for protection against infection. The Dermcidin gene encodes an antimicrobial peptide DCD-1, which is constitutively expressed in sweat glands, secreted into the sweat, and transported to the epidermal surface. DCD-1 displays antimicrobial activity in response to a variety of pathogenic microorganisms. Overexpression of Dermcidin in breast cancers promotes cell growth and survival, and is coupled with a focal copy number gain of its locus on human chromosome 12q13.2.
Function:
DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat.
Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.
Subcellular Location:
Secreted.
Tissue Specificity:
Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat at a concentration of 1-10 micrograms/ml.
SWISS:
P81605
Gene ID:
117159
Database links:Entrez Gene: 117159 Human
Omim: 606634 Human
SwissProt: P81605 Human
Unigene: 350570 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
人源性多肽Dermcidin(DCD)是最近从人体汗液中分离出来的一种天然活性多肽,其编码基因dermcidin最初被认为在汗腺中特异性表达,并且与其他已知的编码基因没有同源性。DCD在外泌汗腺中组成性表达并分泌到汗液中,其衍生物DCD-1L和DCD-1在较广的pH范围和高盐浓度下具有抗部分细菌和真菌的活性。经证实,以前在人类神经细胞中发现的一种存活促进肽以及人体内与一种鼠恶病质因子同源的多肽均属于DCD衍生物。最新研究发现dermcidin基因在人乳腺癌等肿瘤细胞及肝细胞中可能作为潜在的致癌基因而存在。不仅如此,人们在人类胎盘组织中也发现了dermcidin基因的表达并分离出了DCD。所以,DCD可能作为多功能的活性多肽在肿瘤发生及人体天然免疫系统疾病、神经系统疾病、妊娠相关疾病的病理生理过程中发挥作用。在感染性疾病和炎症上将来有着广泛应用的可能。