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货号： bs-11348R-Cy3 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11348R-Cy3
- 英文名称
- Anti-Hippocalcin/Cy3
- 中文名称
- Cy3标记的神经细胞特异性钙结合蛋白抗体
- 别 名
- BDR 2; BDR2; Calcium binding protein BDR 2; Calcium binding protein BDR2; Calcium-binding protein BDR-2; Hpca; HPCA_HUMAN; Neuron specific calcium binding protein hippocalcin; Neuron specific calcium-binding protein hippocalcin; Neuron-specific calcium-binding protein hippocalcin;P23K.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 结合蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Cow, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 22kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Hippocalcin
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Hippocalcin is a neuron-specific calcium-binding protein found primarily in the plasma membrane of brain and retinal tissue, with increased expression observed in hippocampal pyramidal cells. Through its calcium-dependent signal regulation, hippocalcin can both inhibit rhodopsin kinase and increase phospholipase D2 expression. In order to regulate kinase and phospholipase activity, hippocalcin must bind to the plasma membrane where it can then bind two calcium ions for use in signal regulation. The hippocalcin protein is highly conserved in mouse, rat and human tissue and has a suggested role in neural plasticity and associative memory by contributing to the survival of neurons during aging. The loss of hippocalcin expression is thought to contribute to age-related impairment of post-synaptic functions related to neuronal degradation.
Function:
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds two calcium ions.
Tissue Specificity:
Brain specific.
Post-translational modifications:
Myristoylation facilitates interaction with membranes.
Similarity:
Belongs to the recoverin family.
Contains 4 EF-hand domains.
Database links:Entrez Gene: 3208 Human
Entrez Gene: 509772 Cow
Entrez Gene: 15444 Mouse
Entrez Gene: 29177 Rat
Omim: 142622 Human
SwissProt: Q4PL64 Cow
SwissProt: P84074 Human
SwissProt: P84075 Mouse
SwissProt: P84076 Rat
Unigene: 632391 Human
Unigene: 384452 Mouse
Unigene: 11019 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.