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货号： bs-23741R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-23741R-FITC
- 英文名称
- Anti-Prokineticin 1/FITC
- 中文名称
- FITC标记的内分泌腺衍生血管内皮生长因子抗体
- 别 名
- Prokineticin-1/Endocrine-gland-derived vascular endothelial growth factor; Prokineticin1; Prokineticin 1; EG-VEGF; EG VEGF; EGVEGF; PROK1; EGVEGF; PK1; PRK1; PROK1_HUMAN; Black mamba toxin related protein; Endocrine gland derived vascular endothelial growth factor; Endocrine-gland-derived vascular endothelial growth factor; Mambakine; Prokineticin-1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 神经生物学 信号转导 生长因子和激素
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 9.7kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from mouse Prokineticin 1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. [provided by RefSeq, Sep 2011]
Function:
Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis.
Subcellular Location:
Secreted.
Tissue Specificity:
Localizes to glandular epithelium, stroma and vascular epithelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the steroidogenic glands, ovary, testis, adrenal and placenta.
Similarity:
Belongs to the AVIT (prokineticin) family.
Database links:Entrez Gene: 84432 Human
Entrez Gene: 246691 Mouse
Entrez Gene: 192205 Rat
Omim: 606233 Human
SwissProt: P58294 Human
SwissProt: Q14A28 Mouse
SwissProt: Q8R414 Rat
Unigene: 514793 Human
Unigene: 461353 Mouse
Unigene: 82757 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.