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货号： bs-20893R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20893R-FITC
- 英文名称
- Anti-Tristetraprolin/ZFP36/FITC
- 中文名称
- FITC标记的Tristetraprolin抗体
- 别 名
- G0/G1 switch regulatory protein 24; G0S24; Growth factor-inducible nuclear protein NUP475; NUP475; Protein TIS11A; RNF162A; TIS 11; TIS11; TIS11A; Tristetraprolin; Tristetraproline; TTP; TTP_HUMAN; Zfp-36; ZFP36; Zinc finger protein 36; Zinc finger protein 36 homolog; Zinc finger protein 36, C3H type, homolog (mouse); Zinc finger protein, C3H type, 36 homolog.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 免疫学 染色质和核信号 神经生物学 信号转导 生长因子和激素
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 35kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Tristetr
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
ZFP36 (ZFP36 Ring Finger Protein) is a Protein Coding gene. Among its related pathways are Spinal Cord Injury and ErbB1 downstream signaling. GO annotations related to this gene include poly(A) RNA binding and enzyme binding. An important paralog of this gene is ZFP36L2.
Function:
mRNA-binding protein involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).
Subunit:
Interacts (via C-terminus) with CNOT1.
Subcellular Location:
Nucleus {ECO:0000269|PubMed:15014438}. Cytoplasm {ECO:0000269|PubMed:15014438}. Note=Localizes to stress granules upon energy starvation. phosphorylation by MAPKAPK2 promotes exclusion from stress granules.
Post-translational modifications:
Phosphorylation by MAPKAPK2 increases its stability and binding to 14-3-3 proteins, leading to reduce its ARE affinity leading to inhibition of degradation of ARE-containing transcripts. Phosphorylated upon mitogen stimulation.
Similarity:
Contains 2 C3H1-type zinc fingers.
Database links:EntrezGene: 7538 Human
Entrez Gene: 79426 Rat
Omim: 190700 Human
SwissProt: P26651 Human
SwissProt: P47973 Rat
Unigene: 534052 Human
Unigene: 728064 Human
Unigene: 82737 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.