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货号： bs-20883R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20883R-FITC
- 英文名称
- Anti-MRGPRG/FITC
- 中文名称
- FITC标记的G蛋白偶联受体169抗体
- 别 名
- G protein coupled receptor 169; G protein coupled receptor MRGG; G-protein coupled receptor 169; GPR169; Mas related G protein coupled receptor member G; MAS related GPR member G; Mas-related G-protein coupled receptor member G; MRGG; MRGPRG.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 G蛋白偶联受体 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 32kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MRGPRG
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
MRGG is a 289 amino acid multi-pass membrane protein that functions as an orphan receptor. A member of the G-protein coupled receptor 1 family and Mas subfamily, MRGG is implicated in pain sensation and modulation by regulating nociceptor function. The gene encoding MRGG maps to human chromosome 11, which comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes.
Function:
Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.
Subcellular Location:
Cell membrane.
Similarity:
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Database links:Entrez Gene: 386746 Human
SwissProt: Q86SM5 Human
Unigene: 730306 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.