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货号： bs-19121R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19121R-FITC
- 英文名称
- Anti-TIPRL/FITC
- 中文名称
- FITC标记的TIP41样蛋白抗体
- 别 名
- 1810011K17Rik; dJ69E11.3; MGC3794; Putative MAPK activating protein PM10; Putative MAPK-activating protein PM10; RP1-69E11.1; Tip; TIP41; TIP41-like protein; tiprl; TIPRL_HUMAN; TOR Signaling Pathway Regulator like; Type 2A-interacting protein.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 信号转导 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 31kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TIPRL
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]
Function:
May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.
Subunit:
Isoform 1 interacts with PPP2CA. Isoform 2 does notinteract with PPP2CA. Interacts with PPP2CB, PPP4C and PPP6C.Interacts with IGBP1; the interaction is dependent on PPP2CA.Associates with a protein phosphatase 2A PP2A(C):alpha-4 complex.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the TIP41 family.
Database links:Entrez Gene: 261726Human
Entrez Gene: 226591Mouse
Entrez Gene: 360869Rat
Omim: 611807Human
SwissProt: O75663Human
SwissProt: Q8BH58Mouse
SwissProt: A2VCX1Rat
Unigene: 209431Human
Unigene: 21520Mouse
Unigene: 56867Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.