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货号： bs-20310R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20310R-FITC
- 英文名称
- Anti-Erbin/FITC
- 中文名称
- FITC标记的Erbin蛋白抗体
- 别 名
- Densin-180-like protein; Erbb2-interacting protein; ERBB2IP; Erbin; LAP2; LAP2_HUMAN; Protein LAP2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Horse, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 158kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Erbin
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Function:
Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated Tyr-1248 of receptor ERBB2, it may contribute to stabilize this unphosphorylated state
Subunit:
Interacts with ERBB2, BPAG1 and ITGB4. May favor the localization of ERBB2, by restricting its presence to the basolateral membrane of epithelial cells. Also found to interact with ARVCF and delta catenin. Interacts (via C-terminus) with DST Isoform 3 (via N-terminus).
Tissue Specificity:
Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine.
Similarity:
Belongs to the LAP (LRR and PDZ) protein family.
Contains 17 LRR (leucine-rich) repeats.
Contains 1 PDZ (DHR) domain.
Database links:Entrez Gene: 55914Human
Entrez Gene: 59079Mouse
Omim: 606944Human
SwissProt: Q96RT1Human
SwissProt: Q80TH2Mouse
Unigene: 519346Human
Unigene: 591774Human
Unigene: 597241Human
Unigene: 277354Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.