产品中心
当前位置：首页>产品中心Anti-ZNF127/FITC
货号： bs-7149R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-7149R-FITC
- 英文名称
- Anti-ZNF127/FITC
- 中文名称
- FITC标记的锌指蛋白127抗体
- 别 名
- D15S9; Makorin ring finger protein 3; Mkrn3; MKRN3_HUMAN; Probable E3 ubiquitin-protein ligase makorin-3; RING finger protein 63; RNF63; ZFP127; Zinc finger protein 127; ZNF127.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 转录调节因子 锌指蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 57kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ZNF127
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs. This gene is intronless and imprinted, with expression only from the paternal allele. Disruption of the imprinting at this locus may contribute to Prader-Willi syndrome. An antisense RNA of unknown function has been found overlapping this gene. [provided by RefSeq, Jul 2008]
Function:
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.
Tissue Specificity:
Expressed in testis, brain, heart and kidney. Ubiquitously detected at low levels throughout the entire embryo, but expression is highest in the ventricular layers of the brain.
DISEASE:
Expressed at the blastocyst stage and the embryonic days 8-17, as well as in undifferentiated and differentiated embryonic stem cells. Expressed in the arcuate nucleus of both male and female animals. Levels of expression are highest on postnatal days 10 and 12, begin to decline on day 15, and reaches a nadir by days 18 to 22, at which time expression is 10 to 20% of the levels detected at 10 days. The timing of the decline in protein expression correlated with the ages at which arcuate KISS1 and TAC2 have been shown to increase, heralding the onset of puberty.
Similarity:
Contains 3 C3H1-type zinc fingers.
Contains 1 RING-type zinc finger.
Database links:Entrez Gene: 7681Human
Entrez Gene: 22652Mouse
Entrez Gene: 292988Rat
Omim: 603856Human
SwissProt: Q13064Human
SwissProt: Q60764Mouse
Unigene: 679587Human
Unigene: 72964Human
Unigene: 146Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.