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货号： bs-20099R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20099R-FITC
- 英文名称
- Anti-ARL8B/FITC
- 中文名称
- FITC标记的ADP核糖基化样因子8B抗体
- 别 名
- ADP ribosylation factor like 10C; ADP-ribosylation factor-like protein 10C; ADP-ribosylation factor-like protein 8B; ARL10C; ARL8B; ARL8B_HUMAN; FLJ10702; Gie1; Novel small G protein indispensable for equal chromosome segregation 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 细胞周期蛋白 细胞分化 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 22kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ARL8B
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
ADP-ribosylation factors (ARFs) are highly conserved guanine nucleotide binding proteins that enhance the ADP-ribosyltransferase activity of Cholera Toxin. ARF’s are important in eukaryotic vesicular trafficking pathways and they play an essential role in the activation of phospholipase D (PC-PLD). ARL8B (ADP-ribosylation factor-like protein 8B), also known as ARL10C or GIE1, is a 186 amino acid protein that localizes to the late endosome membrane and belongs to the ARL family of ARF-like GTPase proteins. Expressed ubiquitously, ARL8A interacts with Tubulin and is thought to play a role in lysosome motility, as well as in chromosomal segregation. The gene encoding ARL8B maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci.
Function:
May play a role in lysosome motility (PubMed:16537643). May play a role in chromosome segregation (PubMed:15331635).
Subunit:
Interacts with tubulin.
Subcellular Location:
Late endosome membrane. Lysosome membrane. Cytoplasm, cytoskeleton, spindle.
Tissue Specificity:
Ubiquitously expressed.
Similarity:
Belongs to the small GTPase superfamily. Arf family.
Database links:Entrez Gene: 55207 Human
SwissProt: Q9NVJ2 Human
Unigene: 250009 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.