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货号： bs-19772R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19772R-FITC
- 英文名称
- Anti-RBM35B/ESRP2/FITC
- 中文名称
- FITC标记的RNA结合蛋白35B抗体
- 别 名
- Epithelial splicing regulatory protein 2; ESRP 2; ESRP2; ESRP2_HUMAN; FLJ21918; FLJ22248; RBM35B; RNA binding motif protein 35A; RNA binding motif protein 35B; RNA binding protein 35B; RNA-binding motif protein 35B; RNA-binding protein 35B.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 结合蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 78kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human RBM35B/ESRP2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]
Function:
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
Subcellular Location:
Nucleus.
Tissue Specificity:
Epithelial cell-specific.
Similarity:
Belongs to the ESRP family.
Contains 3 RRM (RNA recognition motif) domains.
Database links:Entrez Gene: 510878Cow
Entrez Gene: 80004Human
Entrez Gene: 77411Mouse
Entrez Gene: 307810Rat
Omim: 612960Human
SwissProt: Q9H6T0Human
SwissProt: Q8K0G8Mouse
SwissProt: B2RYJ8Rat
Unigene: 436585Human
Unigene: 592053Human
Unigene: 183003Mouse
Unigene: 137974Rat
Unigene: 231924Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.