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货号： bs-19794R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19794R-FITC
- 英文名称
- Anti-SLC12A4/FITC
- 中文名称
- FITC标记的溶质载体家族蛋白12成员A4抗体
- 别 名
- Electroneutral potassium chloride cotransporter 1; Electroneutral potassium-chloride cotransporter 1; Erythroid K Cl cotransporter 1; Erythroid K-Cl cotransporter 1; FLJ40489; hKCC 1; hKCC1; KCC 1; KCC1; Potassium transport protein; Potassium/chloride cotransporter 1; S12A4_HUMAN; Slc12a4; Solute carrier family 12 (potassium/chloride transporters) member 4; Solute carrier family 12 member 4.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 信号转导 通道蛋白 细胞膜蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 121kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SLC12A4
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Function:
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity). Isoform 4 has no transport activity.
Subcellular Location:
Membrane.
Tissue Specificity:
Ubiquitous. Levels are much higher in erythrocytes from patients with Hb SC and Hb SS compared to normal AA erythrocytes. This may contribute to red blood cell dehydration and to the manifestation of sickle cell disease by increasing the intracellular concentration of HbS. Isoform 1 was not detected in circulating reticulocytes.
Post-translational modifications:
N-glycosylated.
Similarity:
Belongs to the SLC12A transporter family.
Database links:Entrez Gene: 6560Human
Entrez Gene: 20498Mouse
Entrez Gene: 396992Pig
Entrez Gene: 29501Rat
Omim: 604119Human
SwissProt: Q9UP95Human
SwissProt: Q9JIS8Mouse
SwissProt: Q28677Rabbit
SwissProt: Q63632Rat
Unigene: 10094Human
Unigene: 292447Mouse
Unigene: 32091Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.