产品中心
当前位置：首页>产品中心Anti-SETMAR/FITC
货号： bs-19672R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19672R-FITC
- 英文名称
- Anti-SETMAR/FITC
- 中文名称
- FITC标记的组蛋白赖氨酸N-甲基SETMAR抗体
- 别 名
- Histone lysine N methyltransferase; Histone lysine N methyltransferase SETMAR; Hsmar 1; Hsmar1; Mariner transposase Hsmar1; Metnase; SET domain and mariner transposase fusion; SET domain and mariner transposase fusion gene; SET domain and mariner transposase fusion gene containing protein; SET domain and mariner transposase fusion gene-containing protein; Setmar; SETMR_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 77kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SETMAR
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Function:
Histone methyltransferase that methylates Lys-4 and Lys-36 of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 Lys-36. Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA.
Subcellular Location:
Nucleus. Chromosome.
Tissue Specificity:
Widely expressed, with highest expression in placenta and ovary and lowest expression in skeletal muscle.
Similarity:
In the N-terminal section; belongs to the histone-lysine methyltransferase family.
In the C-terminal section; belongs to the mariner transposase family.
Contains 1 post-SET domain.
Contains 1 pre-SET domain.
Contains 1 SET domain.
Database links:Entrez Gene: 6419Human
Omim: 609834Human
SwissProt: Q53H47Human
Unigene: 475300Human
Unigene: 716054Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.