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货号： bs-19622R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19622R-FITC
- 英文名称
- Anti-SECISBP2/FITC
- 中文名称
- FITC标记的硒蛋白SECIS结合蛋白2抗体
- 别 名
- DKFZp686C09169; OTTHUMP00000064929; OTTHUMP00000064930; OTTHUMP00000064931; OTTHUMP00000064932; RP11 89K14.1; SBP 2; SBP2; SEBP2_HUMAN; SECIS binding protein 2; SECIS-binding protein 2; SECISBP 2; SECISBP2; Selenocysteine insertion sequence binding protein 2; Selenocysteine insertion sequence-binding protein 2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 发育生物学 信号转导 干细胞 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 95kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SECISBP2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Function:
Binds to the SECIS element in the 3-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed at high levels in testis.
DISEASE:
Defects in SECISBP2 are a cause of abnormal thyroid hormone metabolism (ATHYHM) [MIM:609698]. This phenotype is associated with a reduction in type II iodothyronine deiodinase activity.
Database links:Entrez Gene: 79048Human
Entrez Gene: 464583Chimpanzee
Entrez Gene: 511202Cow
Entrez Gene: 476351Dog
Entrez Gene: 101128509Gorilla
Entrez Gene: 75420Mouse
Entrez Gene: 79049Rat
Entrez Gene: 697442 Rhesus monkey
Omim: 607693Human
SwissProt: Q96T21Human
SwissProt: Q9QX72Rat
Unigene: 59804Human
Unigene: 25076Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.