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货号： bs-2209R 基本售价： 780.0 元 规格： 50ul
- 规格：50ul
- 价格：780.00元
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-2209R
- 英文名称
- CXCR3
- 中文名称
- 细胞表面趋化因子受体3抗体
- 别 名
- CXC-R3; Interferon-inducible protein 10 receptor; IP-10 receptor; CKR-L2; CD183 antigen; G protein-coupled receptor 9; C-X-C Chemokine receptor; CD183; CXC Motif Receptor 3; CKRL2; CMKAR3; G Protein Coupled Receptor 9; GPR9; IP10; IP10R; MIGR; CXCR3_HUMAN.
- Specific References (6) | bs-2209R has been referenced in 6 publications.[IF=3.06] Zhang, Wen, et al. "The role of CXCR3 in the induction of primary biliary cirrhosis." Clinical and Developmental Immunology 2011 (2011). IHC-P ; Mouse.PubMed:21647407[IF=5.94] Saxena, Amit, et al. "CXCR3-independent actions of the CXC chemokine CXCL10 in the infarcted myocardium and in isolated cardiac fibroblasts are mediated through proteoglycans." Cardiovascular Research (2014): cvu138. Mouse.PubMed:24891401[IF=4.20] Ge, L. P., et al. "Integration of nondegradable polystyrene and degradable gelatin in a core–sheath nanofibrous patch for pelvic reconstruction." International Journal of Nanomedicine 2015:10 3193–3201 IHC-P ; Rat.PubMed:25995629[IF=4.88] Massafra, Vittoria, et al. "Splenic dendritic cell involvement in FXR-mediated amelioration of DSS colitis." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease (2015). IHC-P ; Mouse.PubMed:2655460[IF=2.00] Wang, Jun, et al. "Anti‐inflammatory and retinal protective effects of capsaicin on ischemia‐induced injuries through the release of endogenous somatostatin." Clinical and Experimental Pharmacology and Physiology (2017). IHC-P ; Mouse.PubMed:28429852[IF=2.00] Wang, Jun, et al. "Anti‐inflammatory and retinal protective effects of capsaicin on ischemia‐induced injuries through the release of endogenous somatostatin." Clinical and Experimental Pharmacology and Physiology (2017). IHC-P ; Mouse.PubMed:28429852
- 规格价格
- 50ul/780元购买 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 50ul 100ul 200ul
- 研究领域
- 细胞生物 免疫学 信号转导 细胞周期蛋白 细胞膜受体 G蛋白偶联受体 细胞分化
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Guinea Pig,
- 产品应用
- WB=1:500-2000 Flow-Cyt=0.2μg /test （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 40kDa
- 细胞定位
- 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from mouse CXCR3:301-367/367
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011].
Function:
Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC).
Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HMVEC). Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.
Isoform 3 mediates the activity of CXCL11.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta.
Post-translational modifications:
Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction.
N-glycosylated.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
SWISS:
O88410
Gene ID:
12766
Database links:Entrez Gene: 12766 Mouse
SwissProt: O88410 Mouse
Unigene: 12876 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
- 产品图片
Sample:
heart(mouse) Lysate at 40 ug
Primary: Anti-CXCR3 (bs-2209R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 41kD
Observed band size: 51kD
Sample:
liver(mouse) Lysate at 40 ug
Primary: Anti-CXCR3 (bs-2209R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 41kD
Observed band size: 51kD
Blank control: HCCLM3(blue)
Isotype Control Antibody: Rabbit IgG(orange) ; Secondary Antibody: Goat anti-rabbit IgG-FITC(white blue), Dilution: 1:100 in 1 X PBS containing 0.5% BSA ; Primary Antibody Dilution: 5ul in 100 uL1X PBS containing 0.5% BSA(green).