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货号： bs-18412R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18412R-FITC
- 英文名称
- Anti-LRRC8D/FITC
- 中文名称
- FITC标记的富含亮氨酸重复蛋白8D抗体
- 别 名
- FLJ10470; FLJ20403; LRC8D_HUMAN; Leucine rich repeat containing 5; Leucine rich repeat containing 8 family member D; Leucine rich repeat containing protein 8D; LRRC 5; LRRC 8D; LRRC5.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 98kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human LRRC8D
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
LRRC8D contains 12 LRR (leucine-rich) repeats. The function of this protein is unknown.
Function:
Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8D constitutes a pore-forming subunit or whether it is closely associated with the pore (By similarity). Mediates the import of the antibiotic blasticidin-S into cell (PubMed:24782309).
Subunit:
Heterooligomer; heterooligomerizes with other LRRC8 proteins (LRRC8A, LRRC8B, LRRC8C and/or LRRC8E), possibly to form a heterohexamer.
Subcellular Location:
Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Mainly localizes in the endoplasmic reticulum
Similarity:
Belongs to the LRRC8 family.
Contains 13 LRR (leucine-rich) repeats.
Database links:Entrez Gene: 55144Human
SwissProt: Q7L1W4Human
Unigene: 482087Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.