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货号： bs-17339R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17339R-FITC
- 英文名称
- Anti-hnRNP A0/FITC
- 中文名称
- FITC标记的异质核糖核蛋白A0抗体
- 别 名
- HNRNPA0;Heterogeneous nuclear ribonucleoprotein A0; hnRNA binding protein; hnRNP A0; HNRNPA0; ROA0_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 结合蛋白 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, Cynomolgus Monkey, Rhesus monkey, Gorilla, Marmoset (common)
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 31kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human hnRNP A0
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of polypeptides that contribute to mRNA transcription and pre-mRNA processing as well as mature mRNA transport to the cytoplasm and translation. They also bind heterogeneous nuclear RNA (hnRNA), which are the transcripts produced by RNA polymerase II. There are approximately 20 known hnRNP proteins and their complexes are the major constituents of the spliceosome. The majority of hnRNP protein components are localized to the nucleus; however, some shuttle between the nucleus and the cytoplasm. hnRNP I, also designated polypyrimidine tract-binding protein (PTB), and its homolog hnRNP L, bind to the 3 end of introns to modulate alternative splicing mechanisms of pre-mRNAs in normal cells and the translation of sev-eral viruses, including hepatitis C virus (HCV). The human hnRNP I gene maps to chromosome 19p13.3 and encodes a protein that is localized in the nucleoplasm. hnRNP L, like hnRNP I, is also localized in the nucleoplasm.
Function:
This protein is a component of ribonucleosomes.
Subcellular Location:
Nucleus. Component of ribonucleosomes.
Post-translational modifications:
Arg-291 is dimethylated, probably to asymmetric dimethylarginine.
Similarity:
Contains 2 RRM (RNA recognition motif) domains.
Database links:Entrez Gene: 416302Chicken
Entrez Gene: 745876Chimpanzee
Entrez Gene: 540311Cow
Entrez Gene: 481524Dog
Entrez Gene: 10949Human
Entrez Gene: 77134Mouse
Entrez Gene: 498696Rat
Omim: 609409Human
SwissProt: Q13151Human
SwissProt: Q9CX86Mouse
Unigene: 645902Human
Unigene: 96996Human
Unigene: 490274Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.