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货号： bs-17167R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17167R-FITC
- 英文名称
- Anti-TPIT/FITC
- 中文名称
- FITC标记的TPIT蛋白抗体
- 别 名
- DJ747L4.1; T Box 19; T box factor, pituitary; T box protein 19; T box transcription factor TBX19; T box transcription factor TBX19; TBS 19; TBS19; TBX19; TPIT.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, Chimpanzee,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 48kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TPIT
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure. [provided by RefSeq, Jul 2008]
Function:
Tpit (TBX19, T box 19) is a highly cell-restricted transcription factor belonging to the T-Box family. T box 19 is required for pro-opeiomelanocortin (POMC) gene expression and differentiation of corticotroph and melanotroph cells. Tpit gene mutations have been shown to be directly correlated to pituitary adrenocorticotropin (ACTH) deficiencies. Tpit functions as a transcriptional activator by recruiting the p160 family of coactivators.
Subcellular Location:
Nuclear
Similarity:
Contains 1 T-box DNA-binding domain.
Database links:Entrez Gene: 395793Chicken
Entrez Gene: 514352Cow
Entrez Gene: 449029Dog
Entrez Gene: 9095Human
Entrez Gene: 83993Mouse
Entrez Gene: 304935Rat
Omim: 604614Human
SwissProt: O60806Human
SwissProt: Q99ME7Mouse
Unigene: 190649Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.