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货号： bs-11905R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-11905R
- 英文名称
- NPAS3
- 中文名称
- 神经细胞PAS结构域蛋白3抗体
- 别 名
- Basic helix loop helix PAS protein MOP6; Basic-helix-loop-helix-PAS protein MOP6; bHLHe12; Class E basic helix-loop-helix protein 12; FLJ10003; FLJ11138; FLJ11605; Member of PAS protein 6; MOP 6; MOP6; Neuronal PAS domain containing protein 3; Neuronal PAS domain protein 3; Neuronal PAS domain-containing protein 3; Neuronal PAS3; NPAS 3; NPAS3; NPAS3_HUMAN; PAS domain-containing protein 6; PASD 6; PASD6.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 神经生物学 信号转导 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Sheep,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 101kDa
- 细胞定位
- 细胞核
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NPAS3:21-120/933
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
The Per-Arnt-Sim (PAS) domain is a 270 amino acid motif that mediates associations among various PAS family transcription factors. The PAS family contains neuronal specific transcription factors known as NPAS1, NPAS2 and NPAS3, which are involved the development and maintenance of learning and memory pathways. NPAS1 regulates erythropoietin expression in developing brain. NPAS2, also designated PAS 4/MOP4, associates with MOP3 to activate transcription. NPAS3, which localizes to the nucleus and is ubiquitously expressed in the adult brain, may be involved in neurogenesis and may control regulatory pathways relevant to psychotic illness and to schizophrenia. It regulates tracheal cell fates in the embryo and is necessary for the development of the posterior spiracles and the salivary gland duct. NPAS3 contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain, and 2 PAS (PER-ARNT-SIM) domains. Efficient DNA binding by NPAS2 requires dimerization with another bHLH protein.
Function:
May play a broad role in neurogenesis. May control regulatory pathways relevant to schizophrenia and to psychotic illness.
Subunit:
Efficient DNA binding requires dimerization with another bHLH protein.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitously expressed in the adult brain.
DISEASE:
Note=A chromosomal aberration involving NPAS3 is found in a family with schizophrenia. Translocation t(9;14)(q34;q13).
Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.
Contains 1 PAC (PAS-associated C-terminal) domain.
Contains 2 PAS (PER-ARNT-SIM) domains.
SWISS:
Q8IXF0
Gene ID:
64067
Database links:Entrez Gene: 527053 Cow
Entrez Gene: 100688457 Dog
Entrez Gene: 102191653 Goat
Entrez Gene: 100713384 Guinea pig
Entrez Gene: 100050414 Horse
Entrez Gene: 64067 Human
Entrez Gene: 27386 Mouse
Entrez Gene: 100739785 Pig
Entrez Gene: 299016 Rat
Entrez Gene: 570491 Zebrafish
SwissProt: Q8IXF0 Human
SwissProt: Q9QZQ0 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.