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货号： bs-14566R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-14566R-FITC
- 英文名称
- Anti-ELMO3/FITC
- 中文名称
- FITC标记的ELMO3蛋白抗体
- 别 名
- CED 12; Ced 12 homolog 3; CED12; ELMO 3; ELMO3; ELMO3_HUMAN; Engulfment and cell motility 3; Engulfment and cell motility protein 3; FLJ13824.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 细胞凋亡 新陈代谢
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Guinea Pig,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 69kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ELMO3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Elmo1 associates with DOCK 180 and may influence phagocytosis and effect cell shape changes. Src family kinase mediated tyrosine phosphorylation of ELMO1 influences signaling through Elmo1/Crk/DOCK 180 pathways. Elmo2 interacts directly with Rho G in a GTP-dependent manner and forms a ternary complex with DOCK 180 to induce activation of Rac 1. The RhoG-Elmo2-DOCK 180 pathway is required for activation of Rac 1 and cell spreading mediated by integrin, as well as for neurite outgrowth induced by nerve growth factor. Elmo3 acts in assocation with DOCK180 and Crk II and may be required in complex with DOCK180 to activate Rac/Rho small GTPases.
Function:
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.
Subcellular Location:
Cytoplasm.
Similarity:
Contains 1 ELMO domain.
Contains 1 PH domain.
Database links:Entrez Gene: 79767Human
Entrez Gene: 525427Cow
Entrez Gene: 489763Dog
Entrez Gene: 100734823 Guinea pig
Entrez Gene: 100065878Horse
Entrez Gene: 234683Mouse
Entrez Gene: 100522492Pig
Entrez Gene: 291962Rat
Omim: 606422Human
SwissProt: A6QR40Cow
SwissProt: Q96BJ8Human
SwissProt: Q8BYZ7Mouse
SwissProt: Q499U2Rat
Unigene: 377416Human
Unigene: 237966Mouse
Unigene: 151249Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.