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货号： bs-13997R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13997R-FITC
- 英文名称
- Anti-CORO2B/FITC
- 中文名称
- FITC标记的肌动蛋白结合蛋白2B抗体
- 别 名
- Actin binding protein; Clipin-C; CLIPINC; COR2B_HUMAN; CORO2B; Coronin actin binding protein 2B; Coronin; Coronin-2B; Coronin-like protein C; Protein FC96.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 细胞类型标志物 细胞骨架
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Pig, Cow, Horse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 55kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CORO2B
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Coronins are a family of WD repeat-containing, actin-binding proteins that localize to submembraneous areas and regulate cell motility and cytoskeletal rearrangement. Coronin 1A (CORO1A, CLIPINA, CLABP, TACO, p57) can form coiled coil-mediated homotrimeric complexes that influence early phagosome formation. PKC-dependent phosphorylation of Coronin 1B (CORO1B) at Serine 2 regulates leading edge dynamics and cell motility in fibroblasts through interactions with Arp2/3 complex. Coronin 1C (CORO1C, Coronin 3, HCRNN4) is abundant in differentiating Neuro-2a cells, PC-12 cells and primary oligodendrocytes, where it is thought to influence neuron morphogenesis and migration. Coronin 2A (CORO2A, CLIPINB, IR10, WDR2) is a component of the approximately 1.5-2 megadalton N-CoR (nuclear receptor corepressor) complex of 10-12 proteins, which recruits HDACs to generate repressive chromatin. Coronin 7 (CORO7, CRN7) localizes to the Golgi membrane and influences the organization of intracellular membrane compartments and vesicular trafficking. Coronin 2B (CORO2B, CLIPINC) and Coronin 6 (CORO6) are similar to other members of this family, since they possess a conserved basic N-terminal motif and 3-10 WD repeats clustered in one to two core domains.
Function:
May play a role in the reorganization of neuronal actin structure.
Subunit:
Binds to F-actin and to vinculin.
Subcellular Location:
Cytoplasm; cytoskeleton.
Tissue Specificity:
Expressed predominantly in brain.
Similarity:
Belongs to the WD repeat coronin family.
Contains 5 WD repeats.
Database links:Entrez Gene: 10391Human
Entrez Gene: 235431Mouse
Entrez Gene: 444835 Xenopus laevis
Entrez Gene: 549719 Xenopus tropicalis
Omim: 605002Human
SwissProt: Q9UQ03Human
SwissProt: Q8BH44Mouse
SwissProt: Q6DJD8 Xenopus laevis
SwissProt: A8WGE3 Xenopus tropicalis
Unigene: 551213Human
Unigene: 335229Mouse
Unigene: 24004 Xenopus laevis
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.