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货号： bs-13994R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13994R-FITC
- 英文名称
- Anti-CoREST3/FITC
- 中文名称
- FITC标记的CoREST3蛋白抗体
- 别 名
- 4921514E24Rik; C730034D20Rik; E130101E15Rik; FLJ10876; FLJ16298; RCOR3_HUMAN; KIAA1343; MGC28186; OTTHUMP00000035053; RCOR3; REST corepressor 3; RP11-318L16.1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 56kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CoREST3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
RCOR2 (REST corepressor 2) and RCOR3 (REST corepressor 3) are nuclear proteins that each contain one ELM2 domain and two SANT domains. RCOR2 and RCOR3, both members of the CoREST family, are thought to function as components of the CoREST complex; possibly playing a role in the transcriptional repression of neuronal genes. Additionally, RCOR2 and RCOR3, in conjunction with CoREST, can form immunocomplexes with a variety of histone-modifying genes, including G9a and HDAC1. Via these protein complexes, RCOR2 and RCOR3 can further regulate transcription by controlling the methylation and demethylation of target genes during early development. While RCOR2 is expressed as only one known isoform, RCOR3 exists as two isoforms due to alternative splicing events.
Function:
The CoREST3 gene encodes a functional corepressor required for regulation of neural specific gene expression. REST (RE1 silencing transcription factor 1) can mediate extraneuronal restriction by imposing either active repression via histone deacetylase recruitment or long term gene silencing using a distinct functional complex. Silencing of neuronal specific genes requires the recruitment of an associated corepressor, CoREST, that serves as a functional molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval, including transcriptional units that do not themselves contain REST response elements.
Subcellular Location:
Nuclear
Similarity:
Belongs to the CoREST family.
Contains 1 ELM2 domain.
Contains 2 SANT domains.
Database links:Entrez Gene: 55758Human
Entrez Gene: 214742Mouse
Entrez Gene: 684192Rat
SwissProt: Q9P2K3Human
SwissProt: Q6PGA0Mouse
Unigene: 632489Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.