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货号： bs-13972R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13972R-FITC
- 英文名称
- Anti-Constitutive androstane receptor/FITC
- 中文名称
- FITC标记的雄烷受体CAR抗体
- 别 名
- CAR; CAR BETA; CAR1; CARA; Constitutive activator of retinoid response; Constitutive active response; Constitutive androstane receptor; MGC97144; NR1I3; NR1I3_HUMAN; Nuclear receptor subfamily 1 group I member 3; Orphan nuclear receptor MB67; Orphan nuclear receptor NR1I3.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 转录调节因子 细胞膜受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Chimpanzee,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 45kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Constitutive androstane receptor
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element.
Subcellular Location:
Nucleus. Cytoplasm. Cytoplasm; cytoskeleton. Recruited to the cytoplasm by DNAJC7.
Tissue Specificity:
Predominantly expressed in liver.
Post-translational modifications:
Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation.
Similarity:
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
Database links:Entrez Gene: 9970Human
Entrez Gene: 12355Mouse
Entrez Gene: 65035Rat
Omim: 603881Human
SwissProt: Q14994Human
SwissProt: O35627Mouse
SwissProt: Q9QUS1Rat
Unigene: 349642Human
Unigene: 486506Mouse
Unigene: 163229Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.