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货号： bs-13916R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-13916R-FITC
- 英文名称
- Anti-CHMP7/FITC
- 中文名称
- FITC标记的染色质修饰蛋白CHMP7抗体
- 别 名
- Charged multivesicular body protein 7; CHMP family member 7; Chromatin modifying protein 7; CHMP7_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 51kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CHMP7
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The charged multivesicular body proteins or chromatin modifying proteins, commonly designated CHMPs, belong to the vacuolar sorting protein family and function as chromatin-modifying proteins. CHMP1-6 are all components of ESCRT (endosomal sorting complex required for transport) I, II or III complexes. These complexes are crucial for sorting endosomal articles into multivesicular bodies (MVBs), as well as required for the formation of these bodies. CHMP7 is an ESCRT-III-related protein that associates with CHMP4B. CHMP7 contains an SNF7 domain in the C-terminus and is most similar to CHMP6. CHMP7 also binds to the microtubule interacting and transport (MIT) domain of the deubiquitinating enzyme, UBPY. The overexpression of CHMP7 inhibits EGFR degradation.
Function:
CHMP7 plays a role in the endosomal sorting pathway and is a component of the ESCRT III complex.
Subunit:
Interacts with CHMP4B, but not with VPS25.
Subcellular Location:
Cytoplasm. Note: Diffused localization, with some punctate distribution, especially in the perinuclear area
Similarity:
Belongs to the SNF7 family.
Database links:Entrez Gene: 91782Human
Omim: 611130Human
SwissProt: Q8WUX9Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.