产品中心
当前位置：首页>产品中心Anti-Humanin
货号： bs-11646R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-11646R
- 英文名称
- Humanin
- 中文名称
- 神经保护肽HN抗体
- 别 名
- HN;HUNIN; HUNIN_HUMAN; MT-RNR2; Humanin mitochondrial.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 神经生物学 Alzheimers
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 2.7kDa
- 细胞定位
- 分泌型蛋白
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Humanin:1-24/24
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
Humanin, an endogenous anti-apoptotic peptide against Alzheimer disease-related insults, consists of 24 amino acids. The secreted protein is a neuroprotective factor against death induced by several different types of Alzheimers disease genes. Humanin protects neuronal cells from damage caused by Alzheimers disease genes, specifically APP (amyloid precursor protein). Humanin acts as a ligand for formyl peptide receptor-like 1 (FPRL1) with APP and utilizes its neuroprotective effects by inhibiting FPRL1 access to APP. The peptide prevents Bax translocation from cytosol to mitochondria. Humanin expression levels may be dependent on defects in energy production in muscles with mitochondrial abnormalities. The peptide has been detected in muscles of patients with the mitochondrial disease chronic progressive external ophthalmoplegia (CPEO). Humanin is mainly expressed in the kidney, heart, liver, testis and skeletal muscles.
Function:
Humanin encodes a short polypeptide and abolishes death of neuronal cells caused by multiple different types of familial Alzheimers disease genes and by Abeta amyloid, without effect on death by Q79 or superoxide dismutase 1 mutants. This polypeptide serves as a molecular clue for the development of new therapeutics for Alzheimers disease targeting neuroprotection.
Subunit:
Interacts with BAX, IGFBP3 and TRIM11.
Subcellular Location:
Secreted
Tissue Specificity:
Expressed in the heart, skeletal muscles, kidney and liver. Lesser but significant expression is observed in the brain and the gastrointestinal tract. Expressed in the AD brain, where it is found in some of the large intact neurons of the occipital lobes and small and round reactive glial cells in the hippocampus.
Similarity:
Belongs to the humanin family.
SWISS:
Q8IVG9
Gene ID:
N/A
Database links:Omim: 606120 Human
SwissProt: Q8IVG9 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.