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货号： bs-2140R 基本售价： 380.0 元 规格： 20ul
- 规格：20ul
- 价格：380.00元
- 规格：50ul
- 价格：780.00元
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-2140R
- 英文名称
- IL17
- 中文名称
- 白介素-17抗体
- 别 名
- IL-17; IL 17; IL17; Other Aliases: Interleukin-17; CTLA 8 ; CTLA8; Cytotoxic T lymphocyte associated antigen 8; Cytotoxic T lymphocyte associated protein 8 ; Cytotoxic T lymphocyte associated serine esterase 8; IL 17A; IL17A; Interleukin 17; Interleukin 17A; Interleukin17; Interleukin17A; IL17_HUMAN.
- Specific References (4) | bs-2140R has been referenced in 4 publications.[IF=3.33] Niu, Yinghua, et al. "The balance between intrahepatic IL-17+ T cells and Foxp3+ regulatory T cells plays an important role in HBV-related end-stage liver disease." BMC immunology 12.1 (2011): 47. IHC-P ; Human.PubMed:21851644[IF=1.96] Kou, Wei, et al. "Transforming growth factor-??1 promotes Treg commitment in nasal polyposis after intranasal steroid treatment."Inflammation Research (2013): 1-7.2 ELISA ; Human.PubMed:23178794[IF=1.65] Ghazi, H. F., N. A. Mohammed, and R. J. Hussein. "Tissue IL-17A expression associated with inflammatory lesions and ATG16L1 T300A allele in Crohn’s disease." International Journal of Advanced Research 3.1 (2015): 33-40. IHC-P ; Human.PubMed:not posted yet[IF=1.48] Tang, Wei‑Jing, et al. "Role of T helper 17 cytokines in the tumour immune inflammation response of patients with laryngeal squamous cell carcinoma." Oncology Letters. IHC-P ; Human.PubMed:28693282
- 规格价格
- 50ul/780元购买 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 50ul 100ul 200ul
- 研究领域
- 肿瘤 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 15kDa
- 细胞定位
- 分泌型蛋白
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human IL-17:35-130/155
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
IL17, also known as CTLA8, is a T cell derived hematopoietic cytokine. It was originally cloned from a T cell hybridoma produced by fusion of a mouse cytotoxic T cell clone and a rat T lymphoma. IL17 exhibits multiple biological activities on a variety of cells including: the induction of IL6, IL8 and GCSF production in fibroblasts; the enhancement of surface expression of ICAM 1 in fibroblasts; activation of NF kappaB and costimulation of T cell proliferation. IL17 is an approximately 16 kDa polypeptide of 136 amino acids. The precursor form of IL17 consists of 155 amino acids. To generate the mature IL17 (136 amino acids), the precursor cleaves a 19 amino acid signal peptide. Human IL17 shows approximately 62.5% amino acid homology to mouse IL17 and 58% amino acid homology to rat IL17.
Function:
Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.
Subunit:
Homodimer.
Subcellular Location:
Secreted.
Tissue Specificity:
Restricted to a subset of activated T-cells.
Post-translational modifications:
Found both in glycosylated and nonglycosylated forms.
Similarity:
Belongs to the IL-17 family.
SWISS:
Q16552
Gene ID:
3605
Database links:Entrez Gene: 3605 Human
Entrez Gene: 16171 Mouse
Entrez Gene: 301289 Rat
Omim: 603149 Human
SwissProt: Q16552 Human
SwissProt: Q62386 Mouse
SwissProt: Q61453 Rat
Unigene: 41724 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
白细胞介素17（IL-17A）是一种来源于活化T淋巴细胞的细胞因子,具有较广泛的生物学活性,它能够通过诱导基质细胞产生前炎性细胞因子和造血细胞因子参与机体免疫调节及部分炎症反应，因此白细胞介素IL-17A可能是某些疾病发生发展的重要因素之一。
人IL-17A与人IL-17F的同源性为40%，人与小鼠的IL-17F同源性近80%。Interleukin-17 原称CTLA-8, 是T细胞表达的多肽，参与造血干系统的调节，已经显示IL-17促进纤维母细胞产生IL-6，IL-8和G-CSF。
- 产品图片
Sample:
MOLT-4(Human) Cell Lysate at 30 ug
U937(Human) Cell Lysate at 30 ug
Primary: Anti-IL17 (bs-2140R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 15 kD
Observed band size: 14 kD
Sample: Mcf-7 Cell Lysate at 30 ug
Primary: Anti- IL-17 (bs-2140R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 15 kD
Observed band size: 15 kD
Sample:
Raji(Human) Cell Lysate at 30 ug
Primary: Anti-IL17 (bs-2140R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 15 kD
Observed band size: 14 kD