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货号： bs-1972R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-1972R
- 英文名称
- LCAT
- 中文名称
- 卵磷酯胆固醇酰基转移酶抗体
- 别 名
- LCAT; LCAT_HUMAN; Lecithin cholesterol acyltransferase; Lecithin-cholesterol acyltransferase; Phosphatidylcholine sterol acyltransferase; Phosphatidylcholine-sterol acyltransferase; Phospholipid cholesterol acyltransferase; Phospholipid-cholesterol acyltransferase.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul3N-acetylgalactosamine structures. N-glycosylated sites contain sialylated triantennary and/or biantennary complex structures.
DISEASE:
Lecithin-cholesterol acyltransferase deficiency (LCATD) [MIM:245900]: A disorder of lipoprotein metabolism characterized by inadequate esterification of plasmatic cholesterol. Two clinical forms are recognized: complete LCAT deficiency and fish-eye disease. LCATD is generally referred to the complete form which is associated with absence of both alpha and beta LCAT activities resulting in esterification anomalies involving both HDL (alpha-LCAT activity) and LDL (beta-LCAT activity). It causes a typical triad of diffuse corneal opacities, target cell hemolytic anemia, and proteinuria with renal failure. Note=The disease is caused by mutations affecting the gene represented in this entry.
Fish-eye disease (FED) [MIM:136120]: A disorder of lipoprotein metabolism due to partial lecithin-cholesterol acyltransferase deficiency that affects only alpha-LCAT activity. FED is characterized by low plasma HDL and corneal opacities due to accumulation of cholesterol deposits in the cornea (fish-eye). Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Belongs to the AB hydrolase superfamily. Lipase family.
SWISS:
P04180
Gene ID:
3931
Database links:Entrez Gene: 3931 Human
Entrez Gene: 16816 Mouse
Entrez Gene: 24530 Rat
Omim: 606967 Human
SwissProt: P04180 Human
SwissProt: P16301 Mouse
SwissProt: P18424 Rat
Unigene: 387239 Human
Unigene: 1593 Mouse
Unigene: 10481 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
LCAT是参与体内脂质代谢的主要成份之一，是一种在高密度脂蛋白(HDL)代谢和动脉粥样硬化(AS)发展中的关键酶。LCAT需要经载脂蛋白ApoAI、载脂蛋白D(ApoD)作为辅助因子并经ApoE活化来发挥作用。
- 产品图片
Sample: brain (mouse) Lysate at 40 ug
Primary: Anti- LCAT(bs-1972R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 47kD
Observed band size: 48kD
Sample: K562 (human)Cell Lysate at 40 ug
Primary: Anti- LCAT(bs-1972R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 47kD
Observed band size: 47/52 kD
Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-LCAT Polyclonal Antibody, Unconjugated(bs-1972R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining