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货号： bs-11169R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-11169R
- 英文名称
- Cadherin 10
- 中文名称
- 钙粘附分子10抗体
- 别 名
- cadherin10; cadherin-10; Cadherin 10 (T2 cadherin); Cadherin 10 type 2 (T2 cadherin); Cadherin 10 type 2; Cadherin10; T2 cadherin; CAD10_HUMAN.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 神经生物学 信号转导 细胞粘附分子 细胞骨架 细胞膜蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 82kDa
- 细胞定位
- 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Cadherin 10:31-130/788 <Extracellular>
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
The cadherins are a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. T2-cadherin, also known as cadherin-10 or CDH10, is a 788 amino acid single-pass type I membrane protein that belongs to the cadherin family and contains five cadherin domains. Expressed predominately in brain, but also found in prostate and both adult and fetal kidney, T2-cadherin functions as a calcium-dependent cell adhesion protein that is thought to be involved in the maintenance of synaptic adhesions, axon outgrowth and guidance.
Function:
Cadherin 10 is a type II classical cadherin from the cadherin superfamily. These are integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the proteins homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein
Tissue Specificity:
Predominantly expressed in brain. Also found in adult and fetal kidney. Very low levels detected in prostate and fetal lung.
SWISS:
Q9Y6N8
Gene ID:
1008
Database links:Entrez Gene: 1008 Human
Entrez Gene: 320873 Mouse
Entrez Gene: 29181 Rat
Omim: 604555 Human
SwissProt: Q9Y6N8 Human
SwissProt: P70408 Mouse
Unigene: 92489 Human
Unigene: 117794 Mouse
Unigene: 446240 Mouse
Unigene: 83592 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.