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货号： bs-2579R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-2579R-FITC
- 英文名称
- Anti-Granzyme B + D + E + N + G + F + H/FITC
- 中文名称
- FITC标记的颗粒酶D/B/E/N/G/F/H抗体
- 别 名
- Granzyme D/B/E/N/G/F/H; Granzyme D; Granzyme B; Granzyme E; Granzyme N; Granzyme G; Granzyme F; Granzyme H; Cathepsin G-like 2; CCP-X; CCP3; CCP4; CCP5; CGL-2; CSP-C; Ctla-5; Ctla-6;, Ctla-7; CTLA1; CTSGL2; Grz d; Grz e; Grz f; Grz g; GZMD; Gzme; Gzmf; Gzmg; GZMH; MCSP-2; MCSP-3; MGC117682; Rnkp7; mast cell proteinase-3-like; Cytotoxic T-lymphocyte proteinase; Granzyme H precursor; Cytotoxic serine protease-C; CSP-C; GRAB_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 28kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Granzyme B
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
protease required for lymphocyte cytotoxic granules to lyse target cells [RGD].
Granzyme B is a cysteine protease found in the cytoplasmic lysosome-like granules of cytolytic T lymphocytes (CTL) and natural killer (NK) cells and is is required for the induction of target cell lysis. This occurs as part of cell mediated immune responses, and can activate apoptosis in target cells by both caspase dependent and caspase independent mechanisms.
Function:
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Subcellular Location:
Cytoplasmic granule. Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.
Similarity:
Belongs to the peptidase S1 family. Granzyme subfamily.
Contains 1 peptidase S1 domain.
Database links:Entrez Gene: 3002 Human
Entrez Gene: 14939 Mouse
Entrez Gene: 171528 Rat
Omim: 123910 Human
SwissProt: P10144 Human
SwissProt: P04187 Mouse
SwissProt: P18291 Rat
Unigene: 1051 Human
Unigene: 14874 Mouse
Unigene: 132115 Rat
Unigene: 145789 Rat
Unigene: 21395 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.