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货号： bs-8550R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-8550R-FITC
- 英文名称
- Anti-Coronin 1a/FITC
- 中文名称
- FITC标记的肌动蛋白结合蛋白CORO1A抗体
- 别 名
- actin binding protein; CLABP; Clipin A; Clipin-A; CLIPINA; COR1A_HUMAN; CORO1A; coronin 1; Coronin actin binding protein 1A; Coronin like protein A; Coronin like protein p57; coronin, actin binding protein, 1A; Coronin-1A; Coronin-like protein A; Coronin-like protein p57; p57 antibody TACO; Tryptophan aspartate containing coat protein; Tryptophan aspartate-containing coat protein.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 神经生物学 信号转导 结合蛋白 细胞骨架
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
- 产品应用
- IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 51kDa
- 细胞定位
- 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Coronin 1a
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]
Function:
May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
Subunit:
Binds actin.
Subcellular Location:
Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle, phagosome membrane. Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification.
Tissue Specificity:
Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.
Similarity:
Belongs to the WD repeat coronin family.
Contains 7 WD repeats.
Database links:Entrez Gene: 11151 Human
Entrez Gene: 12721 Mouse
Entrez Gene: 155151 Rat
Omim: 605000 Human
SwissProt: P31146 Human
SwissProt: O89053 Mouse
SwissProt: Q91ZN1 Rat
Unigene: 415067 Human
Unigene: 290482 Mouse
Unigene: 6990 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.