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货号： bs-11037R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-11037R-FITC
- 英文名称
- Anti-TANC1/FITC
- 中文名称
- FITC标记的TANC1蛋白抗体
- 别 名
- ROLSB; Protein TANC1; Rolling pebbles homolog B; TANC; Tanc1; TANC1_HUMAN; Tetratricopeptide repeat ankyrin repeat and coiled coil containing 1; Tetratricopeptide repeat ankyrin repeat and coiled coil domain containing protein 1; TPR domain ankyrin repeat and coiled coil containing.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 神经生物学 信号转导 细胞粘附分子 细胞骨架
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 202kDa
- 细胞定位
- 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TANC1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
- 产品介绍
- background:
TANC (tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein), also known as TANC1, is a 1,861 amino acid postsynaptic cell membrane protein that contains eleven ANK repeats, three TPR repeats and belongs to the TANC family. Considered a scaffolding component in the postsynaptic density, TANC interacts with TNIK, SAPAP1, Alpha-internexin, CaMKII, NMDA 2 and GluR-1. It is also thought that TANC interacts directly with SAP 97, PSD-95 and Homer. Upon stimulation by Rap 2, MINK1 and TNIK may phosphorylate TANC. The TANC gene encodes two alternatively spliced isoforms, contains approximately 264,025 bases and maps to human chromosome 2q24.2. Making up approximately 8% of the human genome, chromosome 2 consists of 237 million bases and encodes over 1,400 genes. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstr鰉 syndrome.
Function:
May be a scaffold component in the postsynaptic density.
Subunit:
Interacts probably directly with DLG1, DLG4, HOMER1. Interacts with DLGAP1, INA, CAMK2A, GRIN2B and GRIA1. Interacts with TNIK. Interacts with MINK1.
Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.
Post-translational modifications:
Phosphorylated; by MINK1 and TNIK upon stimulation by RAP2A.
Similarity:
Belongs to the TANC family.
Contains 11 ANK repeats.
Contains 3 TPR repeats.
Database links:Entrez Gene: 85461 Human
Omim: 611397 Human
SwissProt: Q9C0D5 Human
Unigene: 61590 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.