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货号： bs-8676R-FITC 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-8676R-FITC
- 英文名称
- Anti-IFI-202/FITC
- 中文名称
- FITC标记的γ干扰素诱导蛋白202抗体
- 别 名
- IFI202; IFI 202; fi202a; Ifi202b; Interferon-activable protein 202; Interferon-inducible protein p202; Lupus susceptibility protein p202.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Mouse,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 50kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from mouse IFI-202
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
IFI-202 is a primarily nuclear phosphoprotein which inhibits cell growth, in part by modulating transcriptional activity of NFkB, E2F, AP-1 and p53. Two related human proteins, MNDA (myeloid cell nuclear differentiation antigen) and IFI-16, have also been described. Expression of MNDA has been observed specifically in cells of the granulocyte-macrophage lineage. IFI-16 is constitutively expressed in various T and B cell lines and can be induced by IFN-g in HL60 cells. At least four of the Gene 200 cluster of IFN-inducible proteins, IFI-202, IFI-204, MNDA and IFI-16, are localized in the nucleus.
Function:
Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.
Subunit:
Binds to several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Also binds p53, the hypophosphorylated, growth-inhibitory form of the retinoblastoma protein and the p53-binding protein 1 (53BP1).
Subcellular Location:
Cytoplasm. Nucleus. Note=Accumulates first in the cytoplasm, and is translocated to the nucleus after a delay, where it is primarily chromatin-associated.
Post-translational modifications:
Phosphorylated.
Similarity:
Belongs to the HIN-200 family.
Contains 2 HIN-200 domains.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.