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货号： bs-23488R-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-23488R-AP
- 英文名称
- Anti-glypican 3 /AP
- 中文名称
- 碱性磷酸酶（AP）标记的磷脂酰基醇蛋白聚糖-3抗体
- 别 名
- glypican 3; glypican3; glypican-3; GPC3; Intestinal protein OCI-5; GTR2-2; MXR7.Intestinal protein OCI-5.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human,
- 产品应用
- WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 65kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human glypican 3
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- Constituents: 0.05M TBS, pH 8.0 with 10mg/ml BSA and 0.05% NaN3, 50% glycerol. Or Lyophilized. Buffer = 0.05M TBS, pH 8.0 with 10mg/ml BSA and 0.05% NaN3. Reconstitute with sterile distilled water.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Function:
Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.
Subcellular Location:
Cell membrane and Secreted, extracellular space.
Tissue Specificity:
Highly expressed in lung, liver and kidney.
DISEASE:
Defects in GPC3 are the cause of Simpson-Golabi-Behmel syndrome type 1 (SGBS1) [MIM:312870]; also known as Simpson dysmorphia syndrome (SDYS). SGBS is a condition characterized by pre- and postnatal overgrowth (gigantism) with visceral and skeletal anomalies.
Similarity:
Belongs to the glypican family.
Database links:Entrez Gene: 2719Human
Entrez Gene: 14734Mouse
Entrez Gene: 25236Rat
Omim: 300037Human
SwissProt: P51654Human
SwissProt: Q8CFZ4Mouse
SwissProt: P13265Rat
Unigene: 644108Human
Unigene: 22515Mouse
Unigene: 9717Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
GPC-3磷脂酰基醇蛋白聚糖-3是一种硫酸类肝素蛋白多糖，GPC-3在不同的组织中具有不同的生物学功能，甚至起着完全不同的作用，可能与肿瘤组织类型、发病机制等密切相关．GPC3在绝大多数HCC(肝细胞癌)患者有表达。