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货号： bsm-51207M-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bsm-51207M-AP
- 英文名称
- Anti-LOX/AP
- 中文名称
- 碱性磷酸酶（AP）标记的小鼠抗蛋白赖氨酸-6-氧化酶单克隆抗体
- 别 名
- lox; LYOX; LYOX_HUMAN; Lysyl oxidase; MGC105112; Protein lysine 6 oxidase; Protein-lysine 6-oxidase.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 心血管 细胞生物 免疫学 信号转导
- 抗体来源
- Mouse
- 克隆类型
- Monoclonal
- 克 隆 号
- 4C3
- 交叉反应
- Human, Mouse, Rat, Pig,
- 产品应用
- WB=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 29kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human LOX
- 亚 型
- IgG2b
- 纯化方法
- affinity purified by Protein G
- 储 存 液
- Constituents: 0.05M TBS, pH 8.0 with 10mg/ml BSA and 0.05% NaN3, 50% glycerol. Or Lyophilized. Buffer = 0.05M TBS, pH 8.0 with 10mg/ml BSA and 0.05% NaN3. Reconstitute with sterile distilled water.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene.
Function:
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression.
Subcellular Location:
Secreted; extracellular space
Tissue Specificity:
Heart, placenta, skeletal muscle, kidney, lung and pancreas.
Post-translational modifications:
The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
Proteolytically activated by BMP1 (By similarity).
Similarity:
Belongs to the lysyl oxidase family.
Database links:Entrez Gene: 396474 Chicken
Entrez Gene: 4015 Human
Entrez Gene: 16948 Mouse
Entrez Gene: 24914 Rat
Omim: 153455 Human
SwissProt: Q05063 Chicken
SwissProt: P28300 Human
SwissProt: P28301 Mouse
SwissProt: P16636 Rat
Unigene: 102267 Human
Unigene: 172 Mouse
Unigene: 11372 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.