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货号： bs-8704R-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-8704R-AP
- 英文名称
- Anti-RBJ/AP
- 中文名称
- 碱性磷酸酶（AP）标记的RBJ蛋白抗体
- 别 名
- DJC27_HUMAN; DKFZp434N211; DnaJ (Hsp40) homolog, subfamily C, member 27; DnaJ homolog subfamily C member 27; DNAJC27; rab and DnaJ domain containing; Rab and DnaJ domain-containing protein; RABJS; Ras associated protein Rap1; RBJ.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 信号转导 结合蛋白 G蛋白信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
- 产品应用
- WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 31kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 2mg/1ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human RBJ
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- Function:
GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.
Subunit:
Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms).
Subcellular Location:
Nucleus.
Tissue Specificity:
Overexpressed in gastrointestinal cancers; expression correlates with later tumor-node-metastasis stages of colorectal cancers.
Similarity:
Belongs to the small GTPase superfamily. Rab family.
Contains 1 J domain.
Database links:Entrez Gene: 402783Chicken
Entrez Gene: 540033Cow
Entrez Gene: 51277Human
Entrez Gene: 217378Mouse
Entrez Gene: 298859Rat
Entrez Gene: 402784Zebrafish
Omim: 613527Human
SwissProt: Q6IMM1Chicken
SwissProt: A5D7F5Cow
SwissProt: Q9NZQ0Human
SwissProt: Q8CFP6Mouse
SwissProt: Q6IML7Rat
SwissProt: Q6IMK3Zebrafish
Unigene: 434993Human
Unigene: 271656Mouse
Unigene: 22692Rat
Unigene: 92915Zebrafish
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.