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货号： bs-8386R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-8386R
- 英文名称
- Ecadherin binding protein E7
- 中文名称
- 上皮钙粘附分子结合蛋白E7
- 别 名
- c-Cbl-like protein 1; CasBrM (murine) ecotropic retroviral transforming sequencelike 1; Casitas B-lineage lymphoma transforming sequence-like protein 1; Casitas B-lineage lymphoma-like 1; Casitas B-lineage lymphoma-transforming sequence-like protein 1; cbll1; E3 ubiquitin-protein ligase Hakai; Ecadherin binding protein E7; FLJ23109; HAKAI; HAKAI_HUMAN; MGC163403; OTTHUMP00000206720; OTTHUMP00000206722; OTTHUMP00000206724; RING finger protein 188; RNF188; MGC163401.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 55kDa
- 细胞定位
- 细胞核
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CBLL1/Ecadherin binding protein E7:221-320/491
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
CBLL1, also known as HAKAI (meaning ‘destruction’ in Japanese), or RNF188 (RING finger protein 188), is a 491 amino acid protein that contains one C2H2-type zinc finger and one RING-type zinc finger. CBLL1 is believed to function as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfers that residue to a protein that is targeted for degradation. More specifically, upon activation of c-Src, CBLL1 interacts with and ubiquitinates tyrosine-phosphorylated E-cadherin, thereby targeting the E-cadherin complex for endocytosis and disrupting epithelial cell-cell contacts. Via its role as an E-cadherin regulator, CBLL1 participates in cell adhesion and may also be involved in the regulation of epithelial-mesenchymal transitions.
Function:
Promotes ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation (By similarity).
Subunit:
Homodimer. Interacts with tyrosine-phosphorylated SRC substrates.
Similarity:
Contains 1 C2H2-type zinc finger.
Contains 1 RING-type zinc finger.
SWISS:
Q75N03
Gene ID:
79872
Database links:Entrez Gene: 79872 Human
Entrez Gene: 104836 Mouse
Entrez Gene: 314028 Rat
Omim: 606872 Human
SwissProt: Q75N03 Human
SwissProt: Q9JIY2 Mouse
Unigene: 592271 Human
Unigene: 273270 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.