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货号： bs-12663R-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-12663R-AP
- 英文名称
- Anti-TMEM66/AP
- 中文名称
- 碱性磷酸酶（AP）标记的跨膜蛋白66抗体
- 别 名
- FLJ22274; FOAP 7; HBV X transactivated gene 3 protein; HBV X-transactivated gene 3 protein; HBV XAg-transactivated protein 3; HSPC035; MGC8721; Protein FOAP 7; Protein FOAP-7; TMEM 66; Tmem66; TMM66_HUMAN; Transmembrane protein 66; XTP3.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 细胞膜蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 34kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TMEM66
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- Function:
Negative regulator of store-operated Ca2+ entry (SOCE) involved in protecting cells from Ca2+ overfilling. In response to cytosolic Ca2+ elevation after endoplasmic reticulum Ca2+ refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca2+ levels, and thus preventing the overload of the cell with excessive Ca2+ ions.
Subunit:
Interacts with STIM1.
Subcellular Location:
Membrane.
Tissue Specificity:
Highly expressed in macrophages.
Similarity:
Belongs to the TMEM66 family.
Database links:Entrez Gene: 51669Human
Entrez Gene: 67887Mouse
Entrez Gene: 290796Rat
Omim: 6147768Human
SwissProt: Q96BY9Human
SwissProt: Q8R3Q0Mouse
SwissProt: Q6AYN2Rat
Unigene: 521487Human
Unigene: 290353Mouse
Unigene: 101865Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.