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货号： bs-19942R-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19942R-AP
- 英文名称
- Anti-TM2D1/AP
- 中文名称
- 碱性磷酸酶（AP）标记的β淀粉样蛋白结合蛋白抗体
- 别 名
- BBP; Beta amyloid binding protein; hBBP; TM2 domain containing 1; TM2 domain containing protein 1; TM2D1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 信号转导 细胞凋亡 Alzheimers
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
- 产品应用
- WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 19kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human TM2D1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene is a beta-amyloid peptide-binding protein. It contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily and known to be important in heterotrimeric G protein activation. Beta-amyloid peptide has been established to be a causative factor in neuron death and the consequent diminution of cognitive abilities observed in Alzheimers disease. This protein may be a target of neurotoxic beta-amyloid peptide, and may mediate cellular vulnerability to beta-amyloid peptide toxicity through a G protein-regulated program of cell death. [provided by RefSeq, Dec 2008]
Function:
May participate in beta-amyloid-induced apoptosis via its interaction with beta-APP42.
Subunit:
Interacts with beta-APP42 (beta-amyloid protein 42) peptide of APP.
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Widely expressed.
Post-translational modifications:
N-glycosylated.
Similarity:
Belongs to the TM2 family.
Database links:Entrez Gene: 83941Human
Entrez Gene: 94043Mouse
Entrez Gene: 362545Rat
Omim: 610080Human
SwissProt: Q9BX74Human
SwissProt: Q99MB3Mouse
Unigene: 656790Human
Unigene: 331719Mouse
Unigene: 198278Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.