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货号： bs-19570R-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19570R-AP
- 英文名称
- Anti-NUT/AP
- 中文名称
- 碱性磷酸酶（AP）标记的睾丸核蛋白NUT抗体
- 别 名
- C15orf55; Chromosome 15 open reading frame 55; DKFZp434O192; MGC138683; MGC138684; Nuclear protein in testis; NUT; NUT_HUMAN; Protein NUT.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 染色质和核信号
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 120kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human NUT
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
nuclear protein in testis is a 1,132 amino acid protein that is specifically expressed in testis. Belonging to the FAM22 family, NUT shuttles between nucleus and cytoplasm via a leptomycin-sensitive pathway. It is suggested that the translocation of the NUT gene is the cause of nuclear protein in testis midline carcinomas (NMC). NMCs are highly aggressive carcinomas typically arising in midline structures in young individuals. These carcinomas are characterized by the presence of a chromosomal rearrangement of the NUT gene on chromosome 15 (15q14), which results in a chromosomal translocation most commonly involving the BRD4 gene on chromosome 19p13. Endogenous BRD-NUT fusion proteins contribute to carcinogenesis by associating with chromatin and interfering with epithelial differentiation.
Subcellular Location:
Cytoplasm. Nucleus. Shuttles between nucleus and cytoplasm.
Tissue Specificity:
Specifically expressed in testis.
Post-translational modifications:
Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export.
DISEASE:
Note=A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with BRD4 which produces a BRD4-NUT fusion protein.
Note=A chromosomal aberration involving NUT is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with BRD3 which produces a BRD3-NUT fusion protein.
Similarity:
Belongs to the FAM22 family.
Database links:Entrez Gene: 256646Human
Omim: 608963Human
SwissProt: Q86Y26Human
Unigene: 525769Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.