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货号： bs-20083R-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-20083R-AP
- 英文名称
- Anti-GPR106/AP
- 中文名称
- 碱性磷酸酶（AP）标记的G蛋白偶联受体106抗体
- 别 名
- G protein coupled receptor 106; G-protein coupled receptor 106; G protein coupled receptor affecting testicular descent; GPR106; GPR-106; GREAT; INSL3R; Leucine rich repeat containing G protein coupled receptor 8; LGR8; Relaxin/insulin-like family peptide receptor 2; Relaxin family peptide receptor 2; Relaxin receptor 2; Relaxin receptor-2; RXFP 2; RXFP-2; RXFP2; RXFPR2; RXFP2_HUMAN; GPCR LGR8.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 神经生物学 信号转导 细胞膜受体 内分泌病 G蛋白偶联受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- 产品应用
- WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 86kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human GPR106
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].
Function:
The activity of this relaxin receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP and may also be a receptor for Leydig insulin-like peptide. LGR8 has been reported in blood, bone marrow, brain, kidney, muscle, testis, thyroid, and uterus.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed mainly in the brain, kidney, muscle, testis, thyroid, uterus, peripheral blood cells and bone marrow.
DISEASE:
Defects in RXFP2 are a cause of cryptorchidism (CRYPTO) [MIM:219050]; also known as impaired testicular descent. It is one of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Contains 1 LDL-receptor class A domain.
Contains 10 LRR (leucine-rich) repeats.
Database links:Entrez Gene: 122042 Human
Entrez Gene: 140498 Mouse
Entrez Gene: 363866 Rat
Omim: 606655 Human
SwissProt: Q8WXD0 Human
SwissProt: Q91ZZ5 Mouse
Unigene: 680763 Human
Unigene: 444643 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.