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货号： bs-19376R-AP 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19376R-AP
- 英文名称
- Anti-SAMD8/AP
- 中文名称
- 碱性磷酸酶（AP）标记的SAMD8蛋白抗体
- 别 名
- 1110053F04Rik; 1700010P07Rik; FLJ25082; MGC118303; RP11-487I5.5; SMSr; Sphingomyelin synthase related; Sphingomyelin synthase related protein 1; Sterile alpha motif domain containing 8.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Horse, Rabbit,
- 产品应用
- WB=1:50-200 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 48kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human SAMD8
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
SAMD8 is a multi-pass membrane protein. It belongs to the sphingomyelin synthase family and contains 1 SAM (sterile alpha motif) domain. The function of the SAMD8 protein remains unknown.
Function:
Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.
Similarity:
Belongs to the sphingomyelin synthase family.
Database links:Entrez Gene: 142891Human
Entrez Gene: 67630Mouse
Entrez Gene: 305684Rat
Omim: 611575Human
SwissProt: Q96LT4Human
SwissProt: Q9DA37Mouse
SwissProt: Q641X0Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.