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货号： bs-0065R 基本售价： 380.0 元 规格： 20ul
- 规格：20ul
- 价格：380.00元
- 规格：50ul
- 价格：780.00元
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-0065R
- 英文名称
- Substance P
- 中文名称
- P物质抗体
- 别 名
- Hs.2563; Neurokinin 1; Neurokinin 2; Neurokinin A; Neurokinin alpha; Neuromedin L; Neuropeptide gamma; NKA; NKNA; PPT; Protachykinin 1 precursor; Substance K; Substance P; TAC1; TAC2; Tachykinin 1; Tachykinin 2; Tachykinin precursor 1; Tachykinin1; TACI; TKN1_HUMAN.
- Specific References (5) | bs-0065R has been referenced in 5 publications.[IF=2.94] Tu, Guihua, et al. "P2X< sub>7 inhibition in stellate ganglia prevents the increased sympathoexcitatory reflex via sensory-sympathetic coupling induced by myocardial ischemic injury." Brain research bulletin (2013). Rat.PubMed:23688519[IF=2.63] Liu, Jun, et al. "Sensory–sympathetic coupling in superior cervical ganglia after myocardial ischemic injury facilitates sympathoexcitatory action via P2X7 receptor." Purinergic Signalling (2013): 1-17. Rat.PubMed:23754120[IF=0.78] Liu, Zhi-ming, et al. "Mutual Effect between Neuropeptides and Inflammatory Cytokines in Neurogenic SMSCs of Human Temporomandibular Joint." J Huazhong Univ Sci Technol [Med Sci] 34.4 (2014): 602-607. WB ; Human.PubMed:25135735[IF=4.85] Daschil, Nina, et al. "L-Type calcium channel blockers and substance P induce angiogenesis of cortical vessels associated with beta-amyloid plaques in an Alzheimer mouse model." Neurobiology of Aging (2015). IHC-F ; Mouse.PubMed:25619662[IF=1.89] Yu, Xi-Jiao, et al. "Expression of substance P in rat periodontal alveolar bone after denervation." International Journal of Clinical and Experimental Pathology 9.2 (2016): 1384-1391. IHC-P ; Rat.PubMed:not posted yet
- 规格价格
- 50ul/780元购买 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 50ul 100ul 200ul
- 研究领域
- 神经生物学 新陈代谢
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, G
- 产品应用
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 1.4/13kDa
- 细胞定位
- 分泌型蛋白
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Substance P:58-68/129
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Subcellular Location:
Secreted.
Similarity:
Belongs to the tachykinin family.
SWISS:
P20366
Gene ID:
6863
Database links:Entrez Gene: 6863 Human
Entrez Gene: 21333 Mouse
Entrez Gene: 24806 Rat
Omim: 162320 Human
SwissProt: P20366 Human
SwissProt: P41539 Mouse
SwissProt: P06767 Rat
Unigene: 2563 Human
UniProtKB/Swiss-Prot: P20366.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
P物质（Substance P）是脑组织及消化道中发现的一种神经递质肽。由130个氨基酸残基组成，胃肠道中肌肉收缩的有力促进剂，亦为强血管扩张剂。
SP是一种脑肠肽，亦是最早发现的一种神经肽，属于速激肽家族成员，它广泛分布于中枢及外周神经系统，作为一种神经递质或调质参与疼痛、免疫、心血管等多种生理功能的调节。SP与其它的递质或调质类似，能作用于多种类型的受体，速激肽家族有NK1、NK2、NK3三种受体，都能与SP结合，其中NK1与SP的结合能力最强而被称为SP受体。
- 产品图片
Blank control: Mouse brain cells (blue).
Primary Antibody:Rabbit Anti- Substance P antibody(bs-0065R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions );
Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
Protocol
The cells were fixed with 2% paraformaldehyde (10 min). Primary antibody (bs-0065R, 1μg /1x10^6 cells) were incubated for 30 min on the ice, followed by 1 X PBS containing 0.5% BSA + 1 0% goat serum (15 min) to block non-specific protein-protein interactions. Then the Goat Anti-rabbit IgG/PE antibody was added into the blocking buffer mentioned above to react with the primary antibody at 1/200 dilution for 30 min on ice. Acquisition of 20,000 events was performed.