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货号： bs-7794R 基本售价： 1380.0 元 规格： 100ul
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-7794R
- 英文名称
- DIS3
- 中文名称
- 有丝分裂控制蛋白dis3抗体
- 别 名
- Dis3;DIS3 mitotic control homolog (S. cerevisiae);dis3p;Exosome complex exonuclease RRP44;Mitotic control protein dis3 homolog;Protein DIS3 homolog;Ribosomal RNA processing protein 44;Ribosomal RNA-processing protein 44;RRP44;RRP44_HUMAN.
- 规格价格
- 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 100ul 200ul
- 研究领域
- 细胞生物 细胞周期蛋白 细胞分化 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Horse, Rabbit,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 105kDa
- 细胞定位
- 细胞核 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human DIS3:701-800/958
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
Component of the exosome that has both 3-5 exonuclease and endonuclease activities. Required for the 3-processing of the 7S pre-RNA to the mature nuclear complex. As part of nucleoplasmic and probably cytoplasmic forms of the RNA exosome complex, it is involved in RNA processing and turnover. Also associated with the GTPase RAN.
Function:
Putative catalytic component of the RNA exosome complex which has 3->5 exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3 untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3-5 exonuclease and endonuclease activities.
Subunit:
Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic-and nuclear-specific RNA exosome complex forms.
Subcellular Location:
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Note=Predominantly located in the nucleus. According to PubMed:12429849, found in the nucleolus and according to PubMed:20531386, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3.
Tissue Specificity:
Widely expressed.
Similarity:
Belongs to the RNR ribonuclease family.
Contains 1 PINc domain.
SWISS:
Q9Y2L1
Gene ID:
22894
Database links:Entrez Gene: 22894 Human
Entrez Gene: 72662 Mouse
Entrez Gene: 306103 Rat
Omim: 607533 Human
SwissProt: Q9Y2L1 Human
SwissProt: Q9CSH3 Mouse
Unigene: 728935 Human
Unigene: 744104 Human
Unigene: 163339 Mouse
Unigene: 99292 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.