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货号： bs-0337R 基本售价： 380.0 元 规格： 20ul
- 规格：20ul
- 价格：380.00元
- 规格：50ul
- 价格：780.00元
- 规格：100ul
- 价格：1380.00元
- 规格：200ul
- 价格：2200.00元
产品信息
- 产品编号
- bs-0337R
- 英文名称
- Myelin Protein Zero
- 中文名称
- 外周髓磷脂P0蛋白/P0蛋白抗体
- 别 名
- peripheral myelin prothein Zero; MPZ; MPP; Myelin P0 protein; CHM; CMT1; CMT1B; DSS; MYELIN GLYCOPROTEIN P-ZERO; MYELIN PROTEIN PERIPHERAL; Myelin protein zero; P0; MYP0_HUMAN.
- Specific References (5) | bs-0337R has been referenced in 5 publications.[IF=3.73] Li, Junhui, et al. "Relationship between neural alteration and perineural invasion in pancreatic cancer patients with hyperglycemia." PLoS One 6.2 (2011): e17385. IHC-P ; Human.PubMed:21386984[IF=9.91] Schulz, Alexander, et al. ʺNeuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling.ʺ Brain (2013): awt327 IHC-P ; Human.PubMed:24309211[IF=10.76] Schulz, Alexander, et al. "The importance of nerve microenvironment for schwannoma development." Acta Neuropathologica (2016): 1-19. IHC-P ; Mouse.PubMed:27236462[IF=6.00] Röhr, Dominik, et al. "Sodium‐dependent Vitamin C transporter 2 deficiency impairs myelination and remyelination after injury: Roles of collagen and demethylation." Glia (2017). WB, IF(ICC) ; Mouse.PubMed:28456003[IF=2.27] Chitose, Shun‐ichi, et al. "Recurrent laryngeal nerve regeneration using an oriented collagen scaffold containing Schwann cells." The Laryngoscope (2016). IHC-P ; Dog.PubMed:27861947
- 规格价格
- 50ul/780元购买 100ul/1380元购买 200ul/2200元购买 大包装/询价
- 说 明 书
- 50ul 100ul 200ul
- 研究领域
- 神经生物学 信号转导
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 24kDa
- 细胞定位
- 细胞膜
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human P0 protein:175-248/248 <Cytoplasmic>
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
Myelin protein-zero is the major structural protein of peripheral myelin, accounting for more than 50% of the protein present in the sheath of peripheral nerves. Expression of the gene encoding Myelin protein-zero (MPZ) is restricted to Schwann cells; MPZ is not found in the CNS. An integral membrane glycoprotein of ~28kDa, Myelin protein-zero is thought to link adjacent lamellae and thereby stabilize the myelin assembly. The other 3 major components of myelin are myelin basic protein, myelin proteolipid protein and myelin-associated glycoprotein.
Subunit:
Homodimer and homotetramer.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity:
Found only in peripheral nervous system Schwann cells.
Similarity:
Belongs to the myelin P0 protein family.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
SWISS:
P25189
Gene ID:
4359
Database links:Entrez Gene: 4359 Human
Entrez Gene: 17528 Mouse
Omim: 159440 Human
SwissProt: P25189 Human
SwissProt: P27573 Mouse
Unigene: 591486 Human
Unigene: 93883 Human
Unigene: 9986 Mouse
UniProtKB/Swiss-Prot: P25189.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
成熟的周围神经系统髓鞘主要的蛋白为P0蛋白，分子量28KDa，它具有单个跨膜区，是IgG超家族的成员之一。
- 产品图片
Sample:
Spinal cord (Rat) Lysate at 40 ug
Primary: Anti- Myelin Protein Zero (bs-0337R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 24 kD
Observed band size: 29 kD
Sample:
Bone (Mouse) Lysate at 40 ug
Primary: Anti-Myelin Protein Zero (Bs- 0337R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 24 kD
Observed band size: 26 kD