| 货号 | 11349-1mg |
| 描述 | Resiniferatoxin is a natural analog of capsaicin (Item No. 92350) isolated from some plants of the genus Euphorbia, including E. resinifera.1,2 It activates the transient receptor potential cation channel subfamily V member 1 (TrpV1), formerly known as vanilloid receptor 1, with a Ki value of 20 pM.3 It is an extremely potent and selective activator of a sub-population of primary afferent neurons.4,5 |
| 别名 | RTX; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Szallasi, A. The vanilloid (capsaicin) receptor: Receptor types and species differences. General Pharmacology 25(2), 223-243 (1994). 2.Szallasi, A. and Blumberg, P.M. Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor. Life Sciences 47(16), 1399-1408 (1990). 3.Appendino, G.,Cravotto, G.,Palmisano, G., et al. Synthesis and evaluation of phorboid 20-homovanillates: Discovery of a class of ligands binding to the vanilloid (capsaicin) receptor with different degrees of cooperativity. Journal of Medicinal Chemistry 39(16), 3123-3131 (1996). 4.Winter, J.,Dray, A.,Wood, J.N., et al. Cellular mechanism of action of resiniferatoxin: A potent sensory neuron excitotoxin. Brain Research 520(1-2), 131-140 (1990). 5.Szolcsanyi, J.,Szallasi, A.,Szallasi, Z., et al. Resiniferatoxin: An ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons. Journal of Pharmacology and Experimental Therapeutics 255(2), 923-928 (1990). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 628.7 |
| 分子式 | C37H40O9 |
| CAS号 | 57444-62-9 |
| 稳定性 | ≥ 6 months |
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